Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone.
نویسندگان
چکیده
We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 60 3 شماره
صفحات -
تاریخ انتشار 2015